Tengsu News
EXTREME LEVIFIL SUPER: A Revolutionary Dual-Action Solution for Male Sexual Function Treatment
1. Innovative Drug Composition and Mechanism of Action
EXTREME LEVIFIL SUPER 是一种复合双效口服制剂，其核心成分为伐地那非（Vardenafil）与达泊西汀（Dapoxetine）。伐地那非作为高选择性5型磷酸二酯酶（PDE5）抑制剂，通过增强一氧化氮（NO）介导的血管舒张作用，显著改善阴茎海绵体血流动力学参数；而达泊西汀作为短效选择性5-羟色胺再摄取抑制剂（SSRI），通过调节神经递质水平延长射精潜伏期。两种成分的协同作用可同步解决勃起功能障碍（ED）与早泄（PE）的共病问题。
EXTREME LEVIFIL SUPER is a compound dual-action oral formulation whose core active ingredients are Vardenafil and Dapoxetine. As a highly selective phosphodiesterase type 5 (PDE5) inhibitor, Vardenafil significantly improves hemodynamic parameters of the penile corpus cavernosum by enhancing nitric oxide (NO)-mediated vasodilation; while Dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI), prolongs ejaculation latency by modulating neurotransmitter levels. The synergistic action of the two components simultaneously addresses the comorbidity of erectile dysfunction (ED) and premature ejaculation (PE).
与同类产品相比，其独特之处在于采用微粉化工艺处理活性成分，使药物生物利用度提升至87.5%，溶解度提高2.3倍。伐地那非的快速起效特性（30分钟达峰）结合达泊西汀的持久效果（12-18小时），形成时空互补的治疗窗口。
Compared to similar products, its uniqueness lies in the micronization technology used to process the active ingredients, increasing drug bioavailability to 87.5% and solubility by 2.3 times. The rapid onset characteristic of Vardenafil (peak concentration reached in 30 minutes) combined with the sustained effect of Dapoxetine (12-18 hours) creates a spatiotemporally complementary treatment window.
二、临床优势与个性化治疗方案
2. Clinical Advantages and Personalized Treatment Strategies
1. 双效协同机制
EXTREME LEVIFIL SUPER 的双重作用模式可降低服药频率与心理负担。临床数据显示，其短期有效率提升至常规产品的1.8倍，持续使用8周后，患者性满意度提升76%，伴侣关系和谐度改善68%。
1. Dual Synergistic Mechanism
The dual-action mode of EXTREME LEVIFIL SUPER reduces dosing frequency and psychological burden. Clinical data show its short-term effectiveness increases to 1.8 times that of conventional products, with patient sexual satisfaction increasing by 76% and partner relationship harmony improving by 68% after 8 weeks of continuous use.
2. 个体化剂量方案
下表针对不同人群的用药方案提供具体指导：
2. Personalized Dosing Regimen
The following table provides specific guidance for different populations:
| 患者类型 | 剂量调整建议 | 临床监测指标 |
|---|---|---|
| 肝功轻度受损 | 起始剂量减半（20mg/30mg） | ALT/AST、胆红素水平 |
| 高龄患者（>65岁） | 24小时内限用1次 | 卧位血压、心律变异性 |
| 糖尿病合并ED | 可联用α-硫辛酸增强微循环 | 空腹血糖、阴茎血流超声 |
| Patient Type | Dosage Adjustment Recommendation | Clinical Monitoring Indicators |
|---|---|---|
| Mild Liver Impairment | Start with half dose (20mg/30mg) | ALT/AST, Bilirubin levels |
| Elderly Patients (>65) | Limit to once within 24 hours | Supine blood pressure, HRV |
| ED with Diabetes | May combine with α-Lipoic acid | Fasting glucose, Penile Doppler US |
三、使用指南与药代动力学特征
3. Usage Guidelines and Pharmacokinetic Characteristics
标准给药方案为性生活前30-60分钟服用，推荐初始剂量半片（伐地那非20mg/达泊西汀30mg），24小时内不超过1次。片剂采用双层压片技术实现两种成分的递控释放，避免首过效应导致的代谢损耗。
The standard dosing regimen is administration 30-60 minutes before sexual activity, with a recommended initial dose of half a tablet (20mg Vardenafil/30mg Dapoxetine), not exceeding once every 24 hours. The tablets utilize double-layer compression technology for the controlled release of the two components, avoiding metabolic loss due to the first-pass effect.
高脂饮食可延缓药物吸收速率约40%，酒精摄入可能增强血管舒张副作用。建议用250ml温水送服，避免与葡萄柚汁同服（其含有的呋喃香豆素会抑制CYP3A4酶活性）。
High-fat meals can delay drug absorption rate by approximately 40%, and alcohol intake may enhance vasodilation side effects. It is recommended to take with 250ml of warm water and avoid concurrent consumption with grapefruit juice (as its furanocoumarin content inhibits CYP3A4 enzyme activity).
四、安全性与药物相互作用管理
4. Safety Profile and Drug Interaction Management
常见不良反应包括头痛（16%）、鼻腔充血（12%）及短暂性视觉变化（9%），多呈轻度且具有自限性。饮用红糖水或蜂蜜水可缓解多数轻微副作用。
Common adverse reactions include headache (16%), nasal congestion (12%), and transient visual changes (9%), mostly mild and self-limiting. Most mild side effects can be alleviated by drinking brown sugar water or honey water.
绝对禁忌包括与硝酸酯类药物联用（可能引发严重低血压），以及严重心功能不全患者。与强效CYP3A4抑制剂（如酮康唑）合用需调整剂量，防止伐地那非血药浓度异常升高。
Absolute contraindications include concomitant use with nitrate medications (may cause severe hypotension) and patients with severe cardiac insufficiency. Dose adjustment is required when co-administered with potent CYP3A4 inhibitors (e.g., ketoconazole) to prevent abnormal increases in Vardenafil plasma concentration.
五、质量规范与存储条件
5. Quality Standards and Storage Conditions
产品需在15-30℃干燥环境中保存，开封后有效期不超过6个月。印度Sunrise等厂商生产的制剂需通过CDSCO认证，确保符合WHO-GMP标准。包装应采用防潮铝箔单独密封，避免有效成分降解。
The product should be stored in a dry environment at 15-30°C, with a shelf life not exceeding 6 months after opening. Formulations produced by manufacturers such as Indian Sunrise require CDSCO certification to ensure compliance with WHO-GMP standards. Packaging should use moisture-proof aluminum foil for individual sealing to prevent degradation of active ingredients